1. TOPAZ system which used micro fluidic screening chips imposes and extraordinarily low sample burden compared to dispesning platforms-a 96 reagent screen requires only 1ul of sample, or approximately 10nL per reaction. 2. NanoFlex IFC controller automates the setup of diffusion-based protein crystallization. 3. AutoInspeX II optimized position and profile fo diffusion chambers eliminate shadows and dark edges. 4. Crystal Vision software converts raw data into scores that indicate the degree of crystallization activity. 5. Experiment Manager software provides the master scheduling and analysis tools to design and execute experiments from initial screening through scale-up.